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Oncohematology

Breast Cancer Metastasis to Bone Marrow: Cytology

A clinical case of breast cancer metastasizing to the bone marrow, leading to pancytopenia. Morphology of tumor complexes in aspirate.

Anna Belen Anna Belen 1 min
Bone marrow smear: scattered and grouped carcinoma cells
Bone marrow smear: scattered and grouped carcinoma cells
Bone marrow smear: complex of atypical metastatic carcinoma cells
Bone marrow smear: complex of atypical metastatic carcinoma cells
Bone marrow smear: dense syncytium of polymorphic tumor cells
Bone marrow smear: dense syncytium of polymorphic tumor cells
Bone marrow smear, ×10 magnification: total tissue replacement by tumor complexes
Bone marrow smear, ×10 magnification: total tissue replacement by tumor complexes
Bone marrow smear: contact of a tumor cell with a multinucleated osteoclast
Bone marrow smear: contact of a tumor cell with a multinucleated osteoclast

🔬Clinical case from a doctor in 🇮🇱Israel - Anna Belen ✅Metastasis of breast carcinoma to the bone marrow with its complete replacement. ✅Patient, 57 years old, underwent surgery and chemotherapy for breast cancer in 2019. ✅Currently, peripheral blood shows pancytopenia, elevated LDH. ❓Interestingly, could the last photo capture the moment of intercellular interaction between a tumor cell and an osteoclast? ⁉Perhaps it receives a signal for bone resorption.

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