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Oncohematology

Prostate Cancer Metastasis to Bone Marrow: Cytology

Clinical case: bone marrow microscopy in prostate cancer. Evaluation of metastatic involvement, causes of dry tap, and further diagnostic methods.

Elena Belyakova Elena Belyakova 1 min
Bone marrow smear: dense syncytial complex of atypical cells
Bone marrow smear: dense syncytial complex of atypical cells
Bone marrow smear: large cohesive cluster of tumor cells
Bone marrow smear: large cohesive cluster of tumor cells
Bone marrow smear: compact cluster of cells with pronounced polymorphism
Bone marrow smear: compact cluster of cells with pronounced polymorphism
Bone marrow smear: disintegrating cell complex with neutrophils
Bone marrow smear: disintegrating cell complex with neutrophils
Bone marrow smear: symplast-like aggregate of atypical cells
Bone marrow smear: symplast-like aggregate of atypical cells
Bone marrow smear: layer of non-hematopoietic cells in aspirate
Bone marrow smear: layer of non-hematopoietic cells in aspirate
Bone marrow smear: group of tumor cells against a background of disintegration elements
Bone marrow smear: group of tumor cells against a background of disintegration elements
Bone marrow smear: complex of metastatic carcinoma cells
Bone marrow smear: complex of metastatic carcinoma cells
Bone marrow smear: hypocellular background with detritus and leukocytes
Bone marrow smear: hypocellular background with detritus and leukocytes

❗Clinical case from a member of the closed club of hematologists. ✅Male, 63 years old. On the images: microscopy of an extremely hypocellular bone marrow aspirate (“dry tap”). All photos are from the same patient. ✅Clinical data: the man has verified prostate cancer. There is hypercalcemia and focal bone changes. ❓QUESTIONS: ✔Is there a metastasis to the bone marrow? ✔What additional examination do we recommend? ANSWER TOMORROW! 👉The case was kindly provided by Clinical Laboratory Diagnostics physician, Pathologist from St. Petersburg Elena Alexandrovna Belyakova, Department of Molecular Morphology of the E.E. Eichwald Clinic (Center for Differential Diagnosis of Lymphomas) of the I.I. Mechnikov Northwestern State Medical University.

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