Bone marrow is a blood factory. Cell division here has key features:
ACTIVELY DIVIDING: ✅ Hematopoietic stem cells (progenitors) ✅ Blasts (immature leukocyte forms) ✅ Promyelocytes and erythroblasts
DO NOT DIVIDE: ❌Metamyelocytes and all more mature forms ❌Mature blood cells (leukocytes, erythrocytes, platelets)
✅LINEAGE FEATURES: Erythroid (for erythrocytes): Division proceeds only to the polychromatophilic normoblast stage. Then the cell loses its nucleus (enucleation) to become a reticulocyte.
✅Megakaryocytes (for platelets): Follow the path of endomitosis — DNA replicates multiple times, but the cell does not divide. As a result, the giant cell “pinches off” platelets.
✅ Main principle: young cells proliferate, but stop dividing upon maturation to perform their function.
🙏 The publication was kindly provided by Zebiniso Kholmuradova, morphologist, 🇺🇿 Uzbekistan, Kashkadarya Multidisciplinary Children’s Medical Center.
