Lab test interpretation

Multinucleated Giant Cells in Soft Tissue Cytology

Morphology of multinucleated giant cells in bone and soft tissue cytological preparations: cytoplasm, nuclei, and differential diagnosis with osteoclasts.

Cytological preparation, multinucleated giant cell with rounded nuclei
Cytological preparation, multinucleated giant cell with rounded nuclei

Multinucleated giant cells, characteristic of a number of soft tissue and bone lesions, are visualized in the cytological preparation. Their cytoplasm often contains red granules, and the nuclei are round, with an even distribution of chromatin. Sometimes they resemble osteoclasts.

Source: M. Sheaff, N. Singh — Cytopathology: An Introduction (2013).