Oncohematology

Multiple Myeloma: Plasma Cells in Bone Marrow

A clinical case of multiple myeloma in a 56-year-old male: anemia, elevated ESR, bone pain, and proliferation of atypical plasma cells in the bone marrow.

Patient, 56 years old. Hemoglobin — 98 g/L. Leukocytes — 7.8×10⁹/L. Platelets — 97×10⁹/L. ESR — 56 mm/hour.

In the leukocyte differential count: segmented neutrophils — 66%, lymphocytes — 25%, band neutrophils — 5%, monocytes — 4%.

The patient complains of severe back and leg pain.

Myelogram: a significant number of plasma cells and small megakaryocytes are noted.

❓ What pathology can be suspected based on these data? What morphological changes seem unusual to you?

🩺 Share your thoughts in the comments!

🖼 The post includes photographs of microscopic images of the bone marrow.

🙏 The clinical case was kindly provided by Zebiniso Kholmuradova, morphologist, Uzbekistan, Kashkadarya Multidisciplinary Children’s Medical Center.