Oncohematology

Blast vs. Lymphocyte Morphology in Blood Smears

Distinguishing blasts from mature lymphocytes in blood smears: evaluating cell size, cytoplasmic basophilia, chromatin density, and nucleoli visualization.

Blood smear: comparison of blast morphology (bottom) and mature lymphocyte (top)
Blood smear: comparison of blast morphology (bottom) and mature lymphocyte (top)

📌BLAST and LYMPHOCYTE 📸They stood side by side specifically for the shot, so you can clearly see how they differ

🔹Size: Blasts are usually larger than a typical lymphocyte.

🔹Cytoplasm: Blasts have scantier and more basophilic cytoplasm compared to a lymphocyte.

🔹Chromatin: Condensed and dense in a lymphocyte. The photo shows that it is darker, richer in color, and uniform (as if the same spot was colored several times with a marker) 🖍️ In a blast, the chromatin is loose, delicate, reticular, with nucleoli present (though not always).

*The description is not universal but provides a basis in most cases.

🙏 The publication was kindly provided by Clinical Laboratory Diagnostics Doctor Tanya Stepanova, Volgograd