🔬Plasma cell vs. proerythroblast? ⚠These blood and bone marrow cells have similar morphology: both exhibit cytoplasmic basophilia and a perinuclear halo.❗BUT: 👉Proerythroblasts have deeply basophilic cytoplasm (dark blue), a high nucleocytoplasmic ratio, and an almost always perfectly round, centrally located nucleus. Occasionally, proerythroblasts may show “ears” (1-2 cytoplasmic protrusions). 👉Plasma cells have a lower nucleocytoplasmic ratio than proerythroblasts (relatively more cytoplasm). The nucleus is eccentrically located, and the chromatin is most often more condensed.
Proerythroblast vs. Plasma Cell: Morphological Distinctions
Key criteria for differential diagnosis of proerythroblasts and plasma cells: nuclear location, cytoplasmic basophilia, and N:C ratio.
