Morphological Signs of MDS in Bone Marrow of a Child

A clinical case of MDS in a 1-year-old child: Harlequin cells, basophilic stippling of erythrocytes, and dyserythropoiesis in a bone marrow smear.

Nadezhda Petrenko 1 min September 2, 2025

Bone marrow smear: Harlequin cell with signs of dysplasia

Bone marrow smear: granulocytic precursors, Harlequin cell

Bone marrow smear: Harlequin cell in a preparation from MDS

Bone marrow smear: mitotic figure of a myeloid cell

Bone marrow smear: erythrocyte with large basophilic stippling

Bone marrow smear: oxyphilic normoblast with an abnormal nucleus

Bone marrow smear: lobulated nucleus of an oxyphilic normoblast

Archival slide from 2009. Bone marrow of a boy, 1 year 1 month old. Noteworthy features: 1-3 photos - Harlequin cells; 4 photo - mitosis of a myeloid cell; 5 photo - large basophilic stippling of an erythrocyte; 6-7 photos - abnormal, lobulated nucleus of an oxyphilic normoblast.

The child was diagnosed with MDS.

Romanowsky-Giemsa staining, x1000 magnification + phone camera magnification.

The material was kindly provided by clinical laboratory diagnostics doctor Nadezhda Petrenko, Blagoveshchensk.

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