Oncohematology

Morphology of Dysplastic Megakaryocytes in MDS

Clinical case of megakaryocytic dysplasia in bone marrow: micromegakaryocytes, hypolobulated nuclei, and 6% myeloblasts in a patient with splenomegaly.

Megakaryocytes of all “sorts”! 🔬A clinical case from a doctor from 🇮🇱Israel - Anna Belen. ✅A 67-year-old patient with thrombocytopenia and splenomegaly. ✅Dysplasia: hypolobulation, microforms, absence of platelet budding; immature forms. ✅Bone marrow immunophenotyping reveals 6% myeloblasts.

✅Histology and genetics results are pending. ❓What cells are indicated in photo 1? How many megakaryocytes can you count in photo 2? Presumptive diagnosis?