Hematology

Erythrocyte Morphology in Thalassemia and Hemoglobinopathies

Peripheral blood smears in beta-thalassemia, sickle cell anemia, and hemoglobinopathies C and E: HbC crystals, sickle and target cells.

🔬Working in the Mediterranean region, I encounter thalassemias and pathological hemoglobins in practice, which I only saw in atlases in Russia. I’ll share my personal collection.

  1. B-thalassemia major Severe changes in the erythroid lineage: Anisocytosis and aniso-chromia of erythrocytes, Target cells, Normoblasts, Basophilic stippling, Pappenheimer bodies, Howell-Jolly bodies
  2. B-thalassemia minor Very minor erythrocyte changes: Hypochromia and occasional target cells.
  3. Sickle cell anemia (Hemoglobinopathy S) Sickle cells
  4. Hemoglobinopathy C Characteristic crystals of pathological hemoglobin C in erythrocytes.
  5. Hemoglobinopathy E A migrant worker from Thailand. Almost all erythrocytes are target cells.

❓Does anyone know why there is no need to present a blood picture of Alpha-thalassemia?