Oncohematology

Monocytic Cell Morphology in Chronic Myelomonocytic Leukemia

Criteria for differentiating monoblasts, promonocytes, and dysplastic monocytes in a blood smear in chronic myelomonocytic leukemia (CMML).

Blood smear: atypical monocytes, promonocytes, and monoblasts in CMML
Blood smear: atypical monocytes, promonocytes, and monoblasts in CMML

🔬 Spectrum of monocytic lineage cells in chronic myelomonocytic leukemia. LEFT: The left column illustrates abnormal monocytes that do not meet the criteria for promonocytes (blast cell equivalents) or monoblasts. RIGHT: Monoblasts are shown in the right column. MIDDLE: The middle column shows various promonocytes with nuclear fine chromatin, similar to monoblasts, but with nuclear folds.

Source: Arber D. A., Orazi A. Update on the pathologic diagnosis of chronic myelomonocytic leukemia //Modern Pathology. – 2019. – Т. 32. – №. 6. – С. 732-740.