Bone marrow cell morphology in vitamin B12 deficiency: maturation asynchrony, megaloblastic erythropoiesis, and abnormal mitotic figures.
Microscopy of bone marrow aspirate. Vitamin B12 deficiency disrupts cell cycle coordination, leading to cells appearing in various division phases, slowed maturation, and increased apoptosis. In vitamin B12 deficiency, the normal cell division process in the bone marrow is impaired, especially for actively proliferating cells.
Photo courtesy of Zebiniso Kholmuradova, morphologist, 🇺🇿 Uzbekistan, Kashkadarya Multidisciplinary Children’s Medical Center.
A clinical case of severe megaloblastic anemia: neurological symptoms, pancytopenia, and morphological signs of dyserythropoiesis in bone marrow smears.
Explore the morphology of megaloblasts in bone marrow aspirates from patients with vitamin B12 deficiency, focusing on asynchronous maturation, chromatin structure, and mitotic figures.
Cytological features of bone marrow aspirate: proerythroblast morphology with nucleoli, megaloblastic erythropoiesis, and binucleated megaloblasts in the smear.
