Hematology

Osteoclast Morphology in Bone Marrow Aspirate

Morphological features of an osteoclast in a normal bone marrow aspirate: granular cytoplasm, multiple homogeneous nuclei with single nucleoli.

Bone marrow smear: multinucleated osteoclast with granular cytoplasm
Bone marrow smear: multinucleated osteoclast with granular cytoplasm

🔬Normal bone marrow aspirate: osteoclast; note the highly granular cytoplasm and multiple nuclei, which are homogeneous in size and have indistinct, medium-sized, single nucleoli.

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👉 Source of this image: Barbara J. Bain – Bone Marrow Pathology, 6th edition, 2025