Hematology

Platelet Formation and Fate of Mature Megakaryocyte Nucleus

How blood platelets are formed: a diagram of megakaryocyte cytoplasm fragmentation and phagocytosis of its residual nucleus by bone marrow macrophages.

Scheme of platelet detachment and extrusion of the mature megakaryocyte nucleus
Scheme of platelet detachment and extrusion of the mature megakaryocyte nucleus

🩸WHERE DOES THE MEGAKARYOCYTE NUCLEUS GO? 👉Diagram in the photo: a. Mature megakaryocyte with future platelets. b. Platelet release from a mature megakaryocyte. Cytoplasm protrusion outwards, and eventual breakdown into individual platelets. ❗The expelled nucleus is then phagocytosed by bone marrow macrophages. Source: McKenzie S. - Clinical laboratory hematology. 2 ed, 2014