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Hematology

Identifying Atypical Cells in Blood Smear with Anemia and Thrombocytopenia

Clinical case: anemia and thrombocytopenia in a 73-year-old female patient, automated monocytosis. Help identify atypical cells in the blood smear.

Editorial team Editorial team 1 min
Hematology analyzer screen with WDF scattergram and flags
Hematology analyzer screen with WDF scattergram and flags
Analyzer screen: leukocytes 10.4×10⁹/L, hemoglobin 76 g/L, platelets 62×10⁹/L
Analyzer screen: leukocytes 10.4×10⁹/L, hemoglobin 76 g/L, platelets 62×10⁹/L
Blood smear: segmented neutrophil and a cell for diagnosis
Blood smear: segmented neutrophil and a cell for diagnosis
Blood smear: cell under study with intense cytoplasmic basophilia
Blood smear: cell under study with intense cytoplasmic basophilia
Blood smear: cell with irregular cytoplasmic contours for the clinical case
Blood smear: cell with irregular cytoplasmic contours for the clinical case
Blood smear: cell morphology for differential diagnosis
Blood smear: cell morphology for differential diagnosis
Blood smear: atypical element with cytoplasmic projections in the field of view
Blood smear: atypical element with cytoplasmic projections in the field of view
Blood smear: round cell with eccentrically located nucleus
Blood smear: round cell with eccentrically located nucleus
Blood smear: segmented neutrophil and the cell in question in the preparation
Blood smear: segmented neutrophil and the cell in question in the preparation

Anonymously. Colleagues, I need help. Female, born 1950. Anemia, thrombocytopenia. The analyzer shows a monocyte fraction. Cells with basophilic nucleus and basophilic cytoplasm. I am having difficulty with differentiation.😔 Could these be megakaryoblasts? Or plasma cells?

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