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Oncohematology

Osteoblasts and Osteoclasts in Bone Marrow Aspirate

Cytological examination of bone marrow in a child with Burkitt's lymphoma: differential diagnosis of osteoclasts, osteoblasts, and tumor cells.

Anna Belen Anna Belen 1 min
Bone marrow smear: large multinucleated osteoclast against a background of erythrocytes
Bone marrow smear: large multinucleated osteoclast against a background of erythrocytes
Bone marrow smear: multinucleated bone marrow stromal cell
Bone marrow smear: multinucleated bone marrow stromal cell
Bone marrow smear: cluster of osteoblasts with basophilic cytoplasm
Bone marrow smear: cluster of osteoblasts with basophilic cytoplasm
Bone marrow smear: multinucleated osteoclast with clearly separated nuclei
Bone marrow smear: multinucleated osteoclast with clearly separated nuclei
Bone marrow smear: giant cell with polymorphic nucleus in the aspirate
Bone marrow smear: giant cell with polymorphic nucleus in the aspirate
Bone marrow smear: group of osteoblasts with eccentric nuclei and a clear zone
Bone marrow smear: group of osteoblasts with eccentric nuclei and a clear zone
Bone marrow smear: large fragment of a stromal cell in the aspirate
Bone marrow smear: large fragment of a stromal cell in the aspirate
Bone marrow smear: segmented neutrophil, normoblast, and stromal cells
Bone marrow smear: segmented neutrophil, normoblast, and stromal cells

A 9-year-old patient diagnosed with Burkitt’s lymphoma. Bone marrow aspiration was performed to rule out its involvement in the pathological process. Name the large cells in photos 1 to 7. In photo 8, besides platelets, we see 5 cells. Which ones?

🔬Photos were kindly provided by the Head of the Morphology/IFT Department of Ha-Emek Medical Center Laboratory, Afula 🇮🇱Israel - Anna Belen.

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