Hematology

Osteoclasts in Bone Marrow Aspirate: Differential Diagnosis

Morphological features of osteoclasts in bone marrow aspirate. Differential diagnosis of multinucleated osteoclasts and megakaryocytes in a smear.

Bone marrow aspirate smear: cluster of multinucleated osteoclasts
Bone marrow aspirate smear: cluster of multinucleated osteoclasts

⚠DO NOT CONFUSE THEM WITH MEGAKARYOCYTES! Bone marrow aspirate (200x magnification; Leishman stain) ❗cluster of osteoclasts. Inset in the upper left corner: osteoclast with “digested” material. Source: Jain M. et al. Osteopetrosis in twin infants mimicking leukemia //Revista brasileira de hematologia e hemoterapia. – 2017. – Т. 39. – С. 372-374.