Clinical Case Patient V., born in 1952, presented with complaints of weakness and spontaneous bruising for one month. Complete blood count showed anemia, leukocytes 14•109/L, platelets 19•109/L. 63% blasts in the leukocyte differential count. Hospitalized. A myelogram was taken with a preliminary diagnosis of “Acute promyelocytic leukemia.” On the day of admission, the hemogram showed 74% blasts. (Photo 1, 2). The myelogram showed 63-82% blasts (photos 3,4), most of which morphologically resembled lymphoblasts, but some also had azurophilic granulation. Cytochemical reactions: myeloperoxidase, contrary to expectations, was positive in 9% of blast cells (photos 5,6), lipids slightly more – 18% positive (photos 7,8), PAS reaction – positive in granular form in 27% of blasts (photos 9,10), which helped to suspect acute biphenotypic leukemia (a rare form in which two types of tumor cells are present simultaneously – lymphoid and myeloid). Immunophenotyping results confirmed acute bilineal leukemia.
🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.
