ACUTE LYMPHOBLASTIC LEUKEMIA B IV (most mature variant) Patient, 36 years old. In the bone marrow aspirate, the number of myelokaryocytes is 193.7 thousand/µL, the number of megakaryocytes is reduced. Blast cells constitute 86%. Blasts are heterogeneous in size with round, irregularly shaped or cleaved nuclei, pronounced basophilia of the cytoplasm; in some cells, cytoplasmic vacuolization is noted. In the photo: Bone marrow. Negative reaction for myeloperoxidase in blasts and positive in neutrophils. Bone marrow picture corresponds to acute lymphoblastic leukemia. Immunophenotype of bone marrow blast cells CD34-HLA-DR+TdT-CD13-MPO-CD33-CD117-CD15-CD64-CD14-cIgM+sIgM+CD19(lambda)+ corresponds to variant IV of B-ALL Source: Lugovskaya S.A. Pochtar M.E. - Hematological Atlas 3rd ed., 2011
Acute Lymphoblastic Leukemia B-IV: Morphology and Immunophenotyping
A case of B-IV acute lymphoblastic leukemia: blast morphology in bone marrow, myeloperoxidase cytochemistry, and immunophenotyping results.
