Acute Myeloid Leukemia: Blasts in Peripheral Blood

A clinical case of acute myeloid leukemia: 87% blasts in a peripheral blood smear, severe anemia, profound thrombocytopenia, and analyzer hemogram.

Ekaterina Nozdrina 1 min April 28, 2026

Peripheral blood smear, blasts with high nuclear-cytoplasmic ratio

Peripheral blood smear, cluster of blasts with delicate chromatin structure

Peripheral blood smear, blasts against a background of erythrocyte poikilocytosis

Peripheral blood smear, blast cells with round nuclei and nucleoli

Peripheral blood smear, blasts and anisocytosis against a background of severe anemia

Peripheral blood smear, blast with basophilic vacuolated cytoplasm

Peripheral blood smear, blast cells with signs of monocytoid differentiation

Peripheral blood smear, blasts and a segmented neutrophil

Peripheral blood smear, large blast with pronounced cytoplasmic vacuolization

Analyzer printout: leukocytosis 41.61×10⁹/L and thrombocytopenia 10×10⁹/L

87% blasts!!! Hemogram data is presented on the last slide. Material - peripheral blood. Patient with acute myeloid leukemia since 2023. Severe anemia (due to the underlying disease and cytostatic treatment). Grade IV thrombocytopenia. Of mixed genesis with hemorrhagic syndrome of the skin and mucous membranes. Comorbid disease - malignant neoplasm of the breast, mastectomy (2005), malignant neoplasm of Paget’s disease of the accessory nipple (excision 2025). The prognosis for such a patient is unfavorable, unfortunately.

🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.