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Oncohematology

Acute Myeloid Leukemia M4: Blast Morphology in Blood

A clinical case of acute myeloid leukemia (AML M4): morphology of blasts in peripheral blood, pancytopenia, and analyzer printout.

Ekaterina Nozdrina Ekaterina Nozdrina 1 min
Blood smear: blast cells with high nuclear-cytoplasmic ratio
Blood smear: blast cells with high nuclear-cytoplasmic ratio
Blood smear: large blast with delicate nuclear chromatin and basophilic cytoplasm
Blood smear: large blast with delicate nuclear chromatin and basophilic cytoplasm
Blood smear: blast cells with round nuclei and visible nucleoli
Blood smear: blast cells with round nuclei and visible nucleoli
Blood smear: single blast in the field of view against a background of altered erythrocytes
Blood smear: single blast in the field of view against a background of altered erythrocytes
Blood smear: blasts with eccentrically located nuclei in AML
Blood smear: blasts with eccentrically located nuclei in AML
Blood smear: blast cell with signs of monocytoid differentiation
Blood smear: blast cell with signs of monocytoid differentiation
Blood smear: cluster of blast cells with signs of myelomonocytic leukemia
Blood smear: cluster of blast cells with signs of myelomonocytic leukemia
Blood smear: blast with signs of a monoblast in peripheral blood
Blood smear: blast with signs of a monoblast in peripheral blood
Analyzer printout: leukocytosis WBC 27.53×10⁹/L, anemia and thrombocytopenia
Analyzer printout: leukocytosis WBC 27.53×10⁹/L, anemia and thrombocytopenia

Peripheral blood blasts 84%. Acute myeloid leukemia. A patient, since February, while on a business trip in another city, experienced weakness, malaise, fever, shortness of breath, and skin hematomas.

Pneumonia was detected, and acute leukemia was suspected (anemia and thrombocytopenia in the hemogram).

Immunophenotyping (IFT) revealed leukemic cells consistent with AML M4. Myelogram showed 81% blast cells.

Currently admitted for treatment of bilateral pneumonia and, after stabilization, for a course of chemotherapy.

🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.

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