Oncohematology

Acute Myeloid Leukemia: Blast Morphology and Cytochemistry

A clinical case of acute myeloid leukemia: hyperleukocytosis, 71% blasts in bone marrow, positive myeloperoxidase, and diffuse PAS reaction.

Sternal aspirate of a 45-year-old female patient, with peripheral blast hyperleukocytosis of 110.63 ×109/L, anemia (hemoglobin 95 g/L, erythrocytes 3.2 ×1012/L), thrombocytopenia (61×10^9/L), and 71% blasts in bone marrow smears. The blast cells are of myeloid origin, MPO is positive, and the PAS reaction is diffuse. Immunophenotyping is recommended to confirm the diagnosis of acute myeloid leukemia.

🙏 The publication was kindly provided by the laboratory physician Alla Alekseenkova of CHUZ Clinical Hospital RZD-Medicine, Smolensk