Leukoformula
RU EN
Oncohematology

Acute Myeloid Leukemia with Antecedent Myelodysplastic Syndrome

Bone marrow findings in AML with antecedent MDS: 19.8% blasts, 68% erythroid hyperplasia, dyserythropoiesis, macrophages, and pancytopenia.

Nana Novikova Nana Novikova 1 min
Bone marrow smear: blast cells and erythroid hyperplasia
Bone marrow smear: blast cells and erythroid hyperplasia
Bone marrow smear: mitotic figures in erythroid cells
Bone marrow smear: mitotic figures in erythroid cells
Bone marrow smear: phagocytosing macrophage and erythropoietic cells
Bone marrow smear: phagocytosing macrophage and erythropoietic cells
Bone marrow smear: megaloblastoid cell forms and blasts
Bone marrow smear: megaloblastoid cell forms and blasts
Bone marrow smear: macrophage and pronounced dyserythropoiesis
Bone marrow smear: macrophage and pronounced dyserythropoiesis
Bone marrow smear: binucleated erythroid precursor
Bone marrow smear: binucleated erythroid precursor
Bone marrow smear: large macrophage with inclusions amidst erythroblasts
Bone marrow smear: large macrophage with inclusions amidst erythroblasts
Analyzer printout: pancytopenia (WBC 3.51, HGB 71 g/L, PLT 76)
Analyzer printout: pancytopenia (WBC 3.51, HGB 71 g/L, PLT 76)
Blood smear: poikilocytosis and pronounced anisocytosis of erythrocytes
Blood smear: poikilocytosis and pronounced anisocytosis of erythrocytes

In the bone marrow aspirate of a female patient with acute myeloid leukemia, with antecedent MDS, the number of blast cells is increased to 19.8%, and the erythroid lineage is expanded to 68.0%. Among the cells of the erythroid lineage, megaloblasts and binucleated forms are observed. Mitotic figures are shown in photo 2, and macrophages in photos 3, 5, and 7. In the peripheral blood (photo 9), anisocytosis and poikilocytosis of erythrocytes are present.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina" Smolensk.

Read next

100%