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Oncohematology

Acute Myeloid Leukemia with Eosinophilia: A Clinical Case

A 26-year-old female patient with AML: pancytopenia, 48% blasts in blood, and eosinophilic hyperplasia in bone marrow. Cell morphology.

Darya Todzhaeva Darya Todzhaeva 1 min
Blood smear, two blasts with large nuclei and a narrow rim of cytoplasm
Blood smear, two blasts with large nuclei and a narrow rim of cytoplasm
Blood smear, an aggregate of three blast cells and a normoblast nucleus nearby
Blood smear, an aggregate of three blast cells and a normoblast nucleus nearby
Blood smear, a blast with basophilic cytoplasm, a myelocyte, and a mature neutrophil
Blood smear, a blast with basophilic cytoplasm, a myelocyte, and a mature neutrophil
Blood smear, a large blast cell in the center of the field of view and a lymphocyte
Blood smear, a large blast cell in the center of the field of view and a lymphocyte
Blood smear, a group of monomorphic blasts with a high nuclear-to-cytoplasmic ratio
Blood smear, a group of monomorphic blasts with a high nuclear-to-cytoplasmic ratio
Bone marrow smear, blast cells next to maturing eosinophils
Bone marrow smear, blast cells next to maturing eosinophils
Bone marrow smear, blasts and a dividing cell in the anaphase stage of mitosis
Bone marrow smear, blasts and a dividing cell in the anaphase stage of mitosis
Bone marrow smear, an accumulation of blasts and an eosinophilic precursor with granulation
Bone marrow smear, an accumulation of blasts and an eosinophilic precursor with granulation
Bone marrow smear, pronounced blast infiltration and atypical granulocytes
Bone marrow smear, pronounced blast infiltration and atypical granulocytes
Bone marrow smear, a complex of blast cells with signs of myeloid differentiation
Bone marrow smear, a complex of blast cells with signs of myeloid differentiation

A 26-year-old female patient was admitted to the ENT department, subsequently transferred to the intensive care unit. WBC - 14.6 thousand/µL HGB - 51 g/L RBC - 1.64 million/µL PLT - 35 thousand/µL Differential count: blasts - 48%, myelocytes - 4%, band neutrophils - 1%, segmented neutrophils - 18%, lymphocytes - 25%, monocytes - 3%, eosinophils - 1% In the bone marrow, blasts - 39.5%, with proliferation of the eosinophilic lineage also noted - 14.5% (of which eosinophilic myelocytes - 5%). Photos 1-5 below show peripheral blood, 6-10 show bone marrow. What are your thoughts, colleagues?

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