Oncohematology

Acute Promyelocytic Leukemia: Hypogranular Variant M3v

Morphology of atypical promyelocytes in hypogranular acute promyelocytic leukemia M3v: bilobed nuclei resembling butterfly wings in bone marrow.

Bone marrow smear: atypical promyelocytes with angel wing-shaped nuclei in APL
Bone marrow smear: atypical promyelocytes with angel wing-shaped nuclei in APL

🔬“Angel Wings” 🩸in the blood of a patient with acute promyelocytic leukemia.

✅The photograph shows a bone marrow aspirate, where atypical promyelocytes have abundant basophilic cytoplasm, as well as a specific nuclear shape (“Angel Wings”🕊 or also called “Butterfly Wings”🦋).

✅Diagnosis. Hypogranular form microgranular variant (according to FAB: M3v).

Source: Zaidi S., Pathology Outlines, January 17th, 2023.