Oncohematology

Acute Promyelocytic Leukemia: Blood Smear & Blasts

A clinical case of acute promyelocytic leukemia: thrombocytopenia, hemorrhagic syndrome, and the morphology of atypical promyelocytes in a blood smear.

Patient, 48 years old. Peripheral blood. Presented to the local therapist with complaints of nosebleeds, hematomas, weakness, and elevated blood pressure for 2 weeks. Was referred to the laboratory for a complete blood count. The photos show the blood on the day of admission. WBC 3.5×10⁹/L RBC 4.2×10¹²/L Hb 131g/l PLT 16×10⁹/L ESR 9 mm/h Blasts 16%

Blast cells (atypical promyelocytes) are characterized by medium size, high nuclear-cytoplasmic ratio, pronounced nuclear polymorphism, with 1-2 nucleoli, and cytoplasm with abundant azurophilic granulation.

Hospitalized in the hematology department, where a diagnosis of acute promyelocytic leukemia was made.

🙏 Publication kindly provided by Alla Voronina