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Oncohematology

Acute Promyelocytic Leukemia: Blood & Bone Marrow Smears

A 73-year-old female patient with suspected acute promyelocytic leukemia: hemogram parameters, atypical promyelocytes in blood and bone marrow.

Darya Todzhaeva Darya Todzhaeva 1 min
Analyzer printout: severe anemia, thrombocytopenia 5×10⁹/L and WBC 5.6×10⁹/L
Analyzer printout: severe anemia, thrombocytopenia 5×10⁹/L and WBC 5.6×10⁹/L
Blood smear: two atypical promyelocytes with basophilic cytoplasm
Blood smear: two atypical promyelocytes with basophilic cytoplasm
Blood smear: atypical promyelocyte with an irregular nuclear contour
Blood smear: atypical promyelocyte with an irregular nuclear contour
Blood smear: atypical promyelocytes in the microscopic field of view
Blood smear: atypical promyelocytes in the microscopic field of view
Bone marrow smear: cluster of atypical promyelocytes of varying maturity
Bone marrow smear: cluster of atypical promyelocytes of varying maturity
Bone marrow smear: predominance of atypical promyelocytes with granulation
Bone marrow smear: predominance of atypical promyelocytes with granulation
Bone marrow smear: blasts and atypical promyelocytes with signs of dysplasia
Bone marrow smear: blasts and atypical promyelocytes with signs of dysplasia
Bone marrow smear: promyelocytic series cells with folded nuclei
Bone marrow smear: promyelocytic series cells with folded nuclei
Bone marrow smear: group of atypical promyelocytes in the aspirate
Bone marrow smear: group of atypical promyelocytes in the aspirate
Bone marrow smear: massive infiltration by atypical promyelocytes
Bone marrow smear: massive infiltration by atypical promyelocytes

Woman, 73 years old Suspected acute promyelocytic leukemia (bone marrow cytochemistry and IFT were not performed) In the CBC, the analyzer distributes atypical promyelocytes sometimes as neutrophils, sometimes as monocytes. When counting the differential (first 4 photos), 25% atypical promyelocytes were found; in the bone marrow, 72% (last 6 photos).

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