Hematology
Proerythroblast vs. Plasma Cell: Morphological Distinctions
Key criteria for differential diagnosis of proerythroblasts and plasma cells: nuclear location, cytoplasmic basophilia, and N:C ratio.
Articles
Blood and bone marrow morphology, clinical cases and diagnostic algorithms. Most of the library is in Russian; the English section is growing.
Most of our material is written in Russian — that is the working language of the community. A few pieces exist in English; the rest of the library is one click away and the photographs need no translation.
Hematology
Platelet Formation and Fate of Mature Megakaryocyte Nucleus
How blood platelets are formed: a diagram of megakaryocyte cytoplasm fragmentation and phagocytosis of its residual nucleus by bone marrow macrophages.
Oncohematology
Neutrophilic Leukemoid Reaction in Multiple Myeloma
Clinical case of neutrophilic leukemoid reaction in multiple myeloma: neutrophil morphology, Döhle bodies, and differential diagnosis with CNL.
Laboratory methods
Myelogram Cell Count: 300 or 500 Cells in Bone Marrow Smear
How many cells to count for a myelogram: comparing WHO recommendations for 500 cells and data on differentiating 300 bone marrow aspirate cells.
Laboratory methods
Light Microscopy in Clinical Laboratory Diagnostics
The role of light microscopy and the laboratory microscope for a clinical laboratory diagnostics physician in differential leukocyte count and peripheral blood smear evaluation.
Oncohematology
Pawn Ball Megakaryocytes in Myelodysplasia
Explore the morphological features of pawn ball megakaryocytes in myelodysplastic syndrome. Understand the diagnostic significance of dysmegakaryocytopoiesis in bone marrow smears.
Hematology
Bone Marrow as a Hematopoietic Organ: History of Discovery
Explore the history of hematopoiesis: Ernst Neumann's 1868 discovery of bone marrow's role and Mikhail Arinkin's 1928 introduction of in vivo bone marrow puncture.
Hematology
Pinocchio Cells in Blood Smear: Lymphocyte Morphology
Morphological features of Pinocchio cells in blood smears during interleukin-2 therapy. Immunophenotype and cytochemical markers of activated T-lymphocytes.
Oncohematology
Granular Blasts vs. Dysplastic Promyelocytes in MDS Morphology
IWGM-MDS criteria for differentiating granular blasts and dysplastic promyelocytes: evaluating the Golgi zone, chromatin, and granularity.
Lab test interpretation
Macrophages in Urine Sediment with Hemolytic Anemia
A clinical case of macrophages found in the urine sediment of a child with hemolytic anemia. Microscopy of native preparation and erythrocyte detritus.
Hematology
Myelogram Indicators in Hematological Diseases
Comparative table of myelogram changes in anemias, infections, leukemias, and agranulocytosis, contrasted with normal bone marrow indicators.
Lab test interpretation
Differential Diagnosis of Hypotrophy in Children
Diagnostic algorithm for hypotrophy in children: assessment of clinical signs, somatic pathologies, infections, and complete blood count parameters.