Oncohematology

KMT2A Gene Rearrangements in Acute Myeloid Leukemia

Genetic rearrangements of the KMT2A gene in acute myeloid leukemia: spectrum of partner genes according to the WHO 5th edition classification (WHO 2022).

Diagram: spectrum of KMT2A gene translocation partner genes according to WHO classification
Diagram: spectrum of KMT2A gene translocation partner genes according to WHO classification

🧬LEUKEMIA is a disease of the genome! 🌈The photograph does not show a rainbow… But a diagram illustrating the number of all possible gene rearrangements of the KMT2A gene. This gives rise to many variants of acute myeloid leukemia. Source: WHO 5th edition Classification of hematolymphoid Tumors, 2022. 😉Will you try to learn all the fusions with KMT2A?