Prolymphocytic Transformation of Chronic Lymphocytic Leukemia

A case of CLL transformation to prolymphocytic leukemia: leukocytosis increased to 162×10⁹/L in 4 months, with up to 40% prolymphocytes in blood smear.

Darya Todzhaeva 1 min October 19, 2019

Blood smear: prolymphocytes with large nucleoli against a background of mature lymphocytes

Peripheral blood smear: atypical lymphoid cells and prolymphocytes

Blood smear: a group of prolymphocytes with distinct central nucleoli

Blood smear: pronounced lymphocytosis with a predominance of transformed cells

Blood smear: morphological heterogeneity of lymphoid elements

Blood smear: cluster of prolymphocytes with abundant cytoplasm and nucleoli

Blood smear: lymphoid cells with signs of prolymphocytic transformation

Hematology analyzer screen: pronounced leukocytosis of 162.0 × 10³/µL

Table of complete blood count dynamics: increase in leukocytosis and prolymphocyte percentage

Transformation of CLL into prolymphocytic leukemia. Over 4 months, the patient underwent CBCs, with the last prolymphocyte count being around 30-40%. Clinical Laboratory Diagnostics Physician, City Clinical Hospital No. 67, Moscow: Dasha Todzhaeva

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