Promegakaryocyte in Bone Marrow in MDS with del(5q)

Bone marrow morphology in MDS with del(5q): discovery of a large promegakaryocyte surrounded by platelets and nucleated cells. Clinical case.

Editorial team 1 min November 1, 2026

Bone marrow smear: large branching promegakaryocyte surrounded by platelets

Bone marrow aspirate showing a large promegakaryocyte surrounded by a cluster of platelets and some nucleated bone marrow cells.

Clinical information: A 74-year-old female diagnosed with MDS with isolated del(5q). Bone marrow aspirate taken at diagnosis, before starting lenalidomide treatment.

Biological information: Complete blood count: Hb 7 g/dL, leukocytes 2.5×10^{9/L (neutrophils 1.0×10}9/L), platelets 221×10^9/L. Biochemistry normal, except for total bilirubin 1.8 g/dL with predominance of indirect fraction.

Sample type: Bone marrow. Stain type: May-Grünwald-Giemsa. Author(s): Carballeira Seoana Laura, Facal Malvar Ana, Loyola Olgado Inés. Workplace: Hematology Department, Montecelo Hospital (Pontevedra University Hospital Complex), Pontevedra, Spain.