Hematology

Neutrophil Pseudo-Pelger-Huët Anomaly in SLE Therapy

Acquired pseudo-Pelger-Huët anomaly in a patient with SLE receiving mycophenolate mofetil: neutrophil morphology and chromatin hypercondensation.

Blood smear: neutrophils with nuclear hyposegmentation and chromatin condensation
Blood smear: neutrophils with nuclear hyposegmentation and chromatin condensation

🔬 Pseudopelgerization in a patient with systemic lupus erythematosus (SLE) A 58-year-old woman with SLE developed acquired pseudo-Pelger-Huët anomaly during treatment with mycophenolate mofetil. Neutrophils show variable nuclear contours and uniformly excessive chromatin condensation.

👉 Source: Zhao Y., Rehder C., Wang E. Pseudo–Pelger‐Huët anomaly in a 58‐year‐old woman treated with mycophenolate mofetil for flare of systemic lupus erythematosus //International Journal of Laboratory Hematology. – 2021. – Т. 43. – №. 1. 🩸 The full article from the International Journal of Laboratory Hematology is available in the Library of Blood and Bone Marrow Mysteries.