Neutrophil Pseudo-Pelger-Huët Anomaly in Chemotherapy

Morphology of hyposegmented neutrophils: pseudo-Pelger-Huët anomaly in a peripheral blood smear during cytostatic chemotherapy.

Alexandra Savelieva 1 min February 13, 2026

Blood smear: hyposegmented neutrophil with a characteristic bilobed nucleus

Peripheral blood smear: neutrophils with nuclear hyposegmentation after chemotherapy

Blood smear: leukocytes with signs of drug-induced pseudo-Pelger anomaly

Blood smear: neutrophil with a pince-nez type nucleus during cytostatic therapy

Blood smear: hyposegmented neutrophil with coarse condensed chromatin

Blood smear: several granulocytes with abnormal nuclear segmentation

Blood smear: monolobar pseudo-Pelger neutrophil with dense chromatin

Blood smear: two Pelgerized neutrophils with characteristic bilobed nuclei

Pseudo-Pelger-Huët anomaly (neutrophil hyposegmentation) during chemotherapy.

🙏 This publication was kindly provided by Alexandra Savelieva

Read next

Pelger-Huët Anomaly: Blood Smear Morphology

Pelger-Huët Anomaly: Blood Smear Morphology

A clinical case of hereditary Pelger-Huët anomaly. Morphological features of neutrophil nuclear hyposegmentation in peripheral blood.

Vera Kirnas 1 min

Eosinophil Dysplasia in Peripheral Blood Smear

Eosinophil Dysplasia in Peripheral Blood Smear

Morphological signs of eosinophil dysplasia: pseudo-Pelger anomaly, residual cytoplasmic basophilia, and atypical granulation in a blood smear.

Editorial team 1 min

Hereditary Leukocyte Morphology Anomalies

Hereditary Leukocyte Morphology Anomalies

Hereditary changes in leukocyte morphology in blood smears: Pelger-Huët, Alder-Reilly anomalies, Chédiak-Higashi, and lazy leukocyte syndromes.

Editorial team 1 min