Lab test interpretation

Spheroplasts in Urine Sediment: Microscopy and Causes

Morphology and detection of spheroplasts in urine sediment microscopy. Mechanism of cell wall-deficient bacteria formation during antibiotic therapy.

Native preparation of urine sediment, bacterial spheroplasts (indicated by arrows)
Native preparation of urine sediment, bacterial spheroplasts (indicated by arrows)

Spheroplasts. Urine microscopy.

🙏 This publication was kindly provided by medical laboratory technician Yulia Podobreeva, Khabarovsk.

❗ Reference information Spheroplasts are bacterial cells that have partially lost their cell wall. They retain the outer membrane and part of the cell wall, thus differing from protoplasts, in which the cell wall is completely removed. They are formed under the action of antibiotics (e.g., penicillin) or lysozyme.