Hematology

Chédiak–Higashi Syndrome: Neutrophil Morphology

Learn about Chédiak–Higashi Syndrome: LYST gene mutation, giant granules in neutrophils on blood smear microscopy, and partial albinism.

🐈Chédiak–Higashi Syndrome in a Persian cat. 👉Photo #1: Neutrophils with large cytoplasmic granules in the blood of a Persian cat with Chédiak–Higashi Syndrome 👉Photo #2: Chédiak–Higashi Syndrome in cats at 5.5 months of age. Symptom of Chédiak–Higashi Syndrome: the affected cat (left) has a much lighter coat color (hypopigmentation) than its healthy littermate (right). The affected cat also suffers from photophobia and has pale yellow-green irises instead of the normal copper color, like its littermate. ✅Chédiak–Higashi Syndrome is a well-studied lysosomal disease, inherited in an autosomal recessive manner, caused by mutations in the lysosomal transport regulator (LYST)