A clinical case of Sézary syndrome: erythroderma, leukocytosis, and lymphoid cells with characteristic cerebriform nuclei in a blood smear.
An elderly man from a rural area was admitted to the emergency department with complaints of severe itching, diffuse erythroderma, and palmoplantar keratoderma.
A complete blood count revealed 42,000 leukocytes per cubic millimeter and marked lymphocytosis with a predominance of lymphoid cells with convoluted, cerebriform nuclei.
The most likely diagnosis: Sézary syndrome, leukemic form of cutaneous T-cell lymphoma.
🔬 Source: from the archive of Brazilian hematologist Marcio Melo
Morphological features of Sezary cells in blood smears: cerebriform nuclei, the role of UV radiation in pathogenesis, and principles of PUVA therapy.
Blood picture in B-cell marginal zone lymphoma: absolute lymphocytosis, cytopenias, and morphological features of atypical lymphocytes in the smear.
Discovery of 31% atypical lymphoid cells with nucleoli and polymorphic nuclei in a blood smear from a patient with acute coronary syndrome: cell morphology.
