Hematology

Stomatocytosis: Erythrocyte Morphology and Causes

What is stomatocytosis, how do stomatocytes appear in a blood smear, and in which hereditary and acquired pathologies are they found?

Stomatocytosis is a rare condition in which the central pallor of erythrocytes has the shape of a “mouth” or “slit”. Stomatocytosis can be hereditary or acquired. The latter is observed in alcoholism, liver diseases, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and thalassemia. It can also occur after the use of certain medications (for example, vinblastine preparations for the treatment of leukemia and lymphoma). Stomatocytosis is possible in heart defects. source: inst:xiaoning.zhang