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Oncohematology

T-Cell Prolymphocytic Leukemia: Morphology and Phenotype

A clinical case of T-cell prolymphocytic leukemia: hyperleukocytosis 444×10⁹/L, cell morphology in blood smear, and characteristic immunophenotype.

Anna Belen Anna Belen 1 min
Blood smear: pronounced lymphocytosis with a predominance of atypical prolymphocytes
Blood smear: pronounced lymphocytosis with a predominance of atypical prolymphocytes
Blood smear: cluster of atypical lymphocytes, neutrophil, and Gumprecht shadows
Blood smear: cluster of atypical lymphocytes, neutrophil, and Gumprecht shadows
Blood smear under immersion: prolymphocytes with irregular nuclear contours and nucleoli
Blood smear under immersion: prolymphocytes with irregular nuclear contours and nucleoli
Blood smear under immersion: polymorphic lymphoid cells and ruptured nuclei
Blood smear under immersion: polymorphic lymphoid cells and ruptured nuclei

✅ A task from the closed club of laboratory hematologists. ❗Patient 81 years old. CBC: WBC 444×10^9/L !!!, Hb 110, PLT 62. Peripheral blood morphology in the photos. 💡 The phenotype is quite characteristic: Positive: CD45, mCD3, CD4, CD5bright, CD7bright, CD2, CD27, CD28, TCR-AB, CD45RO. Negative: CD34, CD117, TDT, CD1a, CD8, CD10, CD56, CD57, TCR-GD, CD45RA.

  1. What is the most probable diagnosis? The first 3 people who answer correctly in the comments will receive an invitation to the closed club.

👉 Photos kindly provided by the Head of the Morphology/IFT Department of the HaEmek Medical Center Laboratory, Afula, Israel - Anna Belen.

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