Oncohematology

Botkin-Gumprecht Shadows in Chronic Lymphocytic Leukemia

What are Botkin-Gumprecht shadows, their formation mechanism during blood smear preparation, and their diagnostic significance in chronic lymphocytic leukemia.

Blood smear: mature lymphocytes and Botkin-Gumprecht shadows in CLL
Blood smear: mature lymphocytes and Botkin-Gumprecht shadows in CLL

Botkin-Gumprecht shadows in chronic lymphocytic leukemia. They represent remnants of destroyed lymphocytes. Botkin-Gumprecht shadows are absent in liquid blood and form during the process of smear preparation.