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Oncohematology

MDS Transformation to Acute Megakaryoblastic Leukemia

A case study of MDS transforming into acute megakaryoblastic leukemia: megakaryoblast morphology in blood and immunophenotyping of the blast population.

Elena Belyakova Elena Belyakova 1 min
Blood smear, clusters of megakaryoblasts with signs of pseudopodia
Blood smear, clusters of megakaryoblasts with signs of pseudopodia
Blood smear, megakaryoblasts of various sizes and a segmented neutrophil
Blood smear, megakaryoblasts of various sizes and a segmented neutrophil
Blood smear, a group of polymorphic megakaryoblasts with cytoplasmic budding
Blood smear, a group of polymorphic megakaryoblasts with cytoplasmic budding
Blood smear, megakaryoblasts with dense chromatin and a neutrophil
Blood smear, megakaryoblasts with dense chromatin and a neutrophil
Blood smear, single megakaryoblasts and a degenerating cell
Blood smear, single megakaryoblasts and a degenerating cell
Blood smear, megakaryoblasts surrounded by an eosinophil and a neutrophil
Blood smear, megakaryoblasts surrounded by an eosinophil and a neutrophil
Blood smear, cluster of large atypical megakaryoblasts
Blood smear, cluster of large atypical megakaryoblasts
Blood smear, a group of four blasts against a background of destroyed cells
Blood smear, a group of four blasts against a background of destroyed cells
Blood smear, polymorphism of megakaryoblasts and a Pelger-Huët neutrophil
Blood smear, polymorphism of megakaryoblasts and a Pelger-Huët neutrophil
Flow cytometry, immunophenotyping plots of megakaryoblasts
Flow cytometry, immunophenotyping plots of megakaryoblasts

❗Female, 66 years old. Megakaryoblasts. Clinical diagnosis: transformation of MDS into acute megakaryoblastic leukemia. 🩸 Peripheral blood, leukocytes WBC- 9.8*10^9/L. Blasts were found in the blood smear. Morphology is presented in the images below. 💡 Immunophenotyping. 70.7% blasts with the phenotype: CD45dim SSCint CD34-/+ CD117+ CD33-/+ CD13+ CD38+ HLA-DR+ CD71+ CD36+ cytCD61+ CD31+ CD7+ cytMPO- cytCD3- cytCD79a- CD19- were detected. 👉 Material kindly provided by clinical laboratory diagnostics physician, pathologist from St. Petersburg Elena Belyakova, Department of Molecular Morphology, E.E. Eichwald Clinic, I.I. Mechnikov Northwestern State Medical University.

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