MDS Transformation to AML: Bone Marrow Findings

Clinical case of MDS transforming to AML: 43% blasts, pronounced clasmatosis, signs of dyserythropoiesis, and cytochemical bone marrow results.

Ekaterina Nozdrina 1 min June 10, 2026

Bone marrow smear: myeloblasts with pronounced cytoplasmic clasmatosis

Bone marrow smear: blast cell with cytoplasmic protrusions

Bone marrow smear: cluster of blasts with irregular cytoplasmic contours

Bone marrow smear: binucleated normoblast, manifestation of dyserythropoiesis

Bone marrow smear: erythrocaryocyte with abnormal nuclear shape and lobulation

Bone marrow smear: intererythroid cytoplasmic bridge and blast

Bone marrow smear: erythroid cells with dysplastic changes

Bone marrow smear: blasts with pseudopods and clasmatosis phenomena

Bone marrow smear: positive cytochemical reaction for phospholipids

Bone marrow smear: phospholipid stain, diffuse-granular reaction in blasts

Myelodysplastic syndrome, transformation to acute myeloid leukemia ‼️ Material - bone marrow. Blast count 43%. Myeloid granularity is frequently observed, occasionally Auer rods. Prominent clasmatosis of the cytoplasm is noteworthy. In the erythroid lineage, signs of dyserythropoiesis are noted (intererythroid cytoplasmic bridges, abnormal nuclear shapes). Photos 9,10 - positive reaction for phospholipids in blasts. Also, a positive reaction for myeloperoxidase in 9% of blasts. PAS reaction - in diffuse form. According to IFT results - 45% blasts, myeloid variant of acute leukemia confirmed.

🙏 Publication kindly provided by Ekaterina Nozdrina, Omsk.