Oncohematology

Elongated Mature Lymphocytes in CLL Blood Smear

Morphology of elongated mature lymphocytes in a blood smear in chronic lymphocytic leukemia. Causes of spindle-shaped cell deformation and the influence of EDTA anticoagulant.

Blood smear: elongated mature lymphocytes with processes in CLL
Blood smear: elongated mature lymphocytes with processes in CLL

This is not villous lymphocytes. This is not hairy lymphocytes.

These are elongated mature lymphocytes.

They can be observed in certain areas of a blood smear in some cases of chronic lymphocytic leukemia.

They arise due to cell fragility and are more often found in smears made without ethylenediaminetetraacetic acid anticoagulant.

🔬 Source: from the archive of Brazilian hematology specialist Marcio Melo