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Hematology

Vitamin B12 Deficiency Anemia: Blood and Bone Marrow

A clinical case of vitamin B12 deficiency anemia: macrocytosis (MCV 118 fL), Howell-Jolly bodies, neutrophil hypersegmentation, and megaloblastic erythropoiesis in the bone marrow.

Татьяна Тюлюбаева Татьяна Тюлюбаева 1 min
Bone marrow smear: megaloblasts and hypersegmented neutrophils
Bone marrow smear: megaloblasts and hypersegmented neutrophils
Bone marrow smear: proliferation of basophilic megaloblasts
Bone marrow smear: proliferation of basophilic megaloblasts
Peripheral blood smear: erythrocytes with Howell-Jolly bodies
Peripheral blood smear: erythrocytes with Howell-Jolly bodies
Peripheral blood smear: erythrocyte with basophilic stippling
Peripheral blood smear: erythrocyte with basophilic stippling
Peripheral blood smear: neutrophils with nuclear hypersegmentation
Peripheral blood smear: neutrophils with nuclear hypersegmentation
Blood smear: nucleated erythroid precursor and Howell-Jolly body
Blood smear: nucleated erythroid precursor and Howell-Jolly body
Hematology analyzer screen: pancytopenia, severe anemia, and MCV 118.1 fL
Hematology analyzer screen: pancytopenia, severe anemia, and MCV 118.1 fL

Vitamin B12 deficiency anemia. Complete blood count data and images of bone marrow aspirate fields of view. “Blue” bone marrow due to the abundance of basophilic megaloblast forms, erythrocyte macrocytosis, Howell-Jolly bodies in erythrocytes, basophilic stippling, hypersegmentation of neutrophil nuclei.

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