Bone Marrow Plasmacyte Vacuolization in Pompe Disease

Morphological features of bone marrow in Pompe disease: pronounced vacuolization of plasma cells, PAS cytochemistry, and acid phosphatase reaction.

Editorial team 1 min May 14, 2024

Bone marrow smear: plasma cell with pronounced cytoplasmic vacuolization

Bone marrow smear: vacuolated plasmacyte next to granulocytes

Bone marrow smear: focal PAS-positive reaction in the cytoplasm of a plasmacyte

Cytochemical staining: high acid phosphatase activity in vacuoles

🔬Glycogen storage disease type II (acid maltase deficiency, Pompe disease). ✅Examination of an adult with severe muscular dystrophy reveals pronounced vacuolization of bone marrow plasma cells. Large positive focal inclusions with glycopeptide were observed in the PAS reaction. 👉Source: Löffler H. - Atlas of Clinical Hematology, 6-ed, 2005

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