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Herpes Simplex Virus in Cervical Cytology

Cytological diagnosis of Herpes Simplex Virus (HSV) in the cervix: multinucleated cells, ground-glass appearance, and mulberry phenomenon.

Editorial team Editorial team 1 min
Cervical cytological smear, large multinucleated cell with nuclear crowding
Cervical cytological smear, large multinucleated cell with nuclear crowding
Cervical cytological preparation, multinucleated cells with blurred chromatin
Cervical cytological preparation, multinucleated cells with blurred chromatin
Cervical smear, multinucleated syncytium with ground-glass appearance against a background of leukocytes
Cervical smear, multinucleated syncytium with ground-glass appearance against a background of leukocytes
Cervical cytological smear, herpetic cell among inflammatory infiltrate
Cervical cytological smear, herpetic cell among inflammatory infiltrate

🔬 Cervix. Herpes simplex virus. Educational material from the Department of Clinical Laboratory Diagnostics, RMACPE.

  • large multinucleated cells (up to 60 µm in diameter)
  • chromatin structure is blurred (ground-glass appearance)
  • nuclear membrane is clearly contoured
  • nuclear crowding, “mulberry” phenomenon

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