Laboratory methods

Impact of Hemolysis on AST Levels in Biochemistry

Analysis of preanalytical error: how unnoticed sample hemolysis leads to falsely elevated AST in blood biochemistry and erroneous suspicion of hepatitis.

Thematic illustration for the analysis of a laboratory error in biochemistry
Thematic illustration for the analysis of a laboratory error in biochemistry

Rubric Error in the biochemistry department. They forgot about sample “hemolysis”. A laboratory employee did not pay attention to obvious hemolysis – the destruction of erythrocytes in the test tube. The AST analysis showed a significant elevation. The patient was mistakenly suspected of acute liver damage (acute hepatitis), while the true causes of enzyme elevation were unrelated to hepatitis. The doctor prescribed unnecessary expensive additional tests.

🙏 Project “Repentance”. This is a special section where everyone can anonymously confess their laboratory error. For this, we have created a special Google form that you can fill out without providing your name.