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Oncohematology

Hairy Cell Leukemia: Blood Picture and Cell Morphology

A clinical case of hairy cell leukemia: leukocytosis up to 99.6×10⁹/L, morphology of hairy cells in a blood smear, and analyzer scattergram.

Darya Todzhaeva Darya Todzhaeva 1 min
Blood test form with pronounced leukocytosis and manual differential count
Blood test form with pronounced leukocytosis and manual differential count
WDF analyzer scattergram with abnormal monocyte population distribution
WDF analyzer scattergram with abnormal monocyte population distribution
Blood smear: hairy cells with thin cytoplasmic projections, manual staining
Blood smear: hairy cells with thin cytoplasmic projections, manual staining
Blood smear: morphology of hairy lymphocytes with Romanowsky staining
Blood smear: morphology of hairy lymphocytes with Romanowsky staining
Blood smear: lymphoid cells with irregular perimeter and cytoplasmic projections
Blood smear: lymphoid cells with irregular perimeter and cytoplasmic projections
Blood smear: hairy cells with homogeneous chromatin structure
Blood smear: hairy cells with homogeneous chromatin structure
Blood smear: typical hairy cell leukemia cells in the field of view
Blood smear: typical hairy cell leukemia cells in the field of view
Blood smear: cluster of cells with a fringed cytoplasmic border
Blood smear: cluster of cells with a fringed cytoplasmic border
Blood smear: hairy cells with automated Romanowsky staining
Blood smear: hairy cells with automated Romanowsky staining
Blood smear: group of hairy cells with characteristic cytoplasmic projections
Blood smear: group of hairy cells with characteristic cytoplasmic projections

Woman, 91 years old, analysis from a polyclinic HGB - 129 g/L RBC - 4.44 million/µL PLT - 105 thousand/µL WBC - 99.6 thousand/µL 84% hairy cells (we don’t perform immunophenotyping, but I don’t think anyone will have doubts) The analyzer initially counted them as monocytes The photos show two different Romanowsky stains, manual (more pink) and automated, 100x magnification and phone zoom

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