Prominent Monocytosis and Blasts in Peripheral Blood Smear

A clinical case of leukocytosis (35.3×10⁹/L) with anemia and 66.5% monocytosis: morphological evaluation of suspicious mononuclear cells and blasts in a peripheral blood smear.

Tatyana Djakova 1 min January 26, 2022

Blood smear: cluster of blast cells with moderate cytoplasm volume

Blood smear: two immature mononuclear cells with round nuclei

Blood smear: blast cell, normoblasts, and mature leukocytes

Blood smear: large cell with a monocytoid nucleus and basophilic cytoplasm

Blood smear: group of blast cells and a segmented neutrophil

Blood smear: two atypical mononuclear cells and a normoblast

Blood smear: immature mononuclear cells with round and kidney-shaped nuclei

Blood smear: atypical mononuclear cell with features of a promyelocyte or promonocyte

Blood smear: two immature cells and a mature segmented neutrophil

Blood smear: mononuclear cell and a normoblast with dense chromatin

From a subscriber. Dear colleagues, I need your advice. Patient approx. 50 years old, acute upper respiratory tract infection (?) as per referral. Leukocytes 35.3 Erythrocytes 3.50 Hemoglobin 78 Platelets 239 In differential count: Neutrophils (abs) 5.9 Lymphocytes (abs) 5.6 Monocytes (abs) 23.4 Eosinophils (abs) 0.01 Basophils (abs) 0.22 Immature granulocytes (abs) 2.01 In percentages: Neutrophils 16.9 Lymphocytes 16.0 Monocytes 66.5 Eosinophils 0.0 Basophils 0.6 Immature granulocytes 5.7 Normoblasts are present, (abs) 3.39, in percentages 9.6

How would you classify the cells in the photos?