Hematology

Bone Marrow Cytology in Hepatosplenomegaly: A Case

Clinical case: An 8-year-old boy with hepatosplenomegaly and pancytopenia. Bone marrow aspirate shows altered macrophages. Determine the diagnosis.

Bone marrow aspirate smear for the diagnostic exercise
Bone marrow aspirate smear for the diagnostic exercise

💡 Exercise from the Closed Club of Laboratory Hematologists. An 8-year-old boy was admitted with complaints of fatigue, weakness, and abdominal pain. Examination revealed hepatosplenomegaly, pallor of the skin, and lymphadenopathy. Complete blood count showed anemia, leukopenia, and thrombocytopenia. Bone marrow aspiration biopsy was performed, revealing macrophages with “foamy” cytoplasm filled with lipid droplets. ❓ Question: What is the most likely diagnosis? A) Gaucher disease B) Niemann-Pick disease C) Langerhans cell histiocytosis D) Reactive hemophagocytic syndrome

The first 3 people who answer correctly in the comments will receive an invitation to the closed club. ANSWER TOMORROW!