Hematology
Congenital Sideroblastic Anemia Due to HSPA9 Gene Mutation
A clinical case of congenital sideroblastic anemia with HSPA9 mutation: blood picture, dyserythropoiesis, and ring sideroblasts in bone marrow.
Tag
Anemias
Hematology
History of Iron Deficiency Anemia and Chlorosis
How iron deficiency anemia was described in the 16th century: chlorosis, maiden's disease, and the first clinical observations by German physician Johannes Lange.
Lab test interpretation
Macrophages in Urine Sediment with Hemolytic Anemia
A clinical case of macrophages found in the urine sediment of a child with hemolytic anemia. Microscopy of native preparation and erythrocyte detritus.
Hematology
Myelogram Indicators in Hematological Diseases
Comparative table of myelogram changes in anemias, infections, leukemias, and agranulocytosis, contrasted with normal bone marrow indicators.
Hematology
Evaluation of a Diagnostic Algorithm for Macrocytic Anemia
An analysis of a proposed diagnostic scheme for macrocytic anemia: sternal puncture, assessment of vitamin B12, folate, reticulocyte, and platelet levels.
Laboratory methods
Indirect Coombs Test: Reaction Setup Diagram
Diagram of the indirect Coombs test (indirect antiglobulin test): detection of circulating incomplete antibodies to red blood cells and agglutination mechanism.
Hematology
Drug-Induced Immune Hemolytic Anemia: Medications
A table of medications causing immune hemolytic anemia and the importance of collecting a pharmacological history when the direct Coombs test is positive.
Hematology
Hemosiderin in Urine in Paroxysmal Nocturnal Hemoglobinuria
Urine sediment in paroxysmal nocturnal hemoglobinuria: microscopy of hemosiderin clumps in epithelial cells and a hyaline cast during hemolysis.
Hematology
Algorithm for Differential Diagnosis of Anemia in Children
A flowchart for the differential diagnosis of anemia in pediatrics: evaluating reticulocytes, iron metabolism, myelogram, and erythrocyte morphology.
Oncohematology
Case Study: Interpreting Blood Test in CLL Patient
A hematology clinical case: evaluate complete blood count parameters in a 70-year-old patient with chronic lymphocytic leukemia and acute deterioration.
Hematology
Blood Smear in Sickle Cell Anemia: Drepanocytes
Erythrocyte morphology in sickle cell anemia: detection of drepanocytes, polychromatophilia, and normoblasts in a peripheral blood smear.
Hematology
Binucleated Megaloblast in Bone Marrow Aspirate
Morphological features of a binucleated megaloblast in bone marrow aspirate in pernicious anemia: chromatin structure and nuclear envelope.